Understand more about Peptides Bioregulators

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Understand more about Peptides Bioregulators
Peptide Bioregulators

FROM EXPERIMENT TO MEDICINAL SUBSTANCES

Long-term investigations performed by the research team of the Institute resulted in creating a new class of geroprotectors – peptide bioregulators. The administration of peptide bioregulators enables effective prevention of premature ageing and therapy of age-related diseases.

 

 

Researchers of the Institute are the inventors of a number of medicinal and prophylactic pharmaceutical substances, which have been adopted by the Russian Ministry of Public Health and are presently under serial production:

  • 6 geroprotective medications (Thymalin, Thymogen, Epithalamin, Prostatilen, Cortexin, Retinalamin);
  • 30 types of cell metabolism bioregulators, 
  • 5 highly efficient synthesized peptides (Vilon, Epitalon, Cortagen, Livagen, Prostamax), which largely have no analogues in other countries.

There were chemically synthesized  over 100 biologically active peptides which revealed the ability to hold back the process of ageing.

 According to the concept of peptide bioregulation, a theory of endogenous peptide bioregulators’ involvement in the maintenance of structural and functional homeostasis of cell populations, containing and producing these factors, was formulated. These endogenous peptides became commonly known as “Cytomedins”.

Cytomedins control gene expression and protein synthesis, thus preventing age-related accumulation of quantitative structural and functional alterations, which are the markers of transition of a biological system from the norm to the pathology. Disordered peptide bioregulation reduces organism resistance to external and internal destabilizing factors, serving a cause of premature ageing.

 

A long record of peptide bioregulators application in the health service  has demonstrated their high effectiveness in combating various disease and pathologies, including those refractory to other medicines.

The researchers developed a new technology for creating biologically active food supplements (parapharmaceuticals), based on peptide complexes isolated from animal organs and tissues. A new group of parapharmaceuticals has received a name of “Cytomaxes”. Biologically active food supplements are produced in the form of tablets and capsules. Cytomaxes exert a regulatory effect on the cellular level and are used for improving the organism resistance to the impact of adverse environmental, climatic, occupational and other factors, as well as during the rehabilitation period after surgeries, traumas, diseases; in case of malnutrition, high physical loads; for the purpose of maintaining the functions of the main organism systems in old and very old persons in order to reduce the risk of disease occurrence.

 

Natural Peptides Combinations

  • Digestive System: A-7 Svetinorm A-1 Suprefort A-10 Stamakort
  • Cardiovascular system: A-3 Ventfort A-14 Chelochart A-6 Vladonix
  • Central nervous system: A-5 Cerluten A-3 Ventfort A-7 Svetinorm
  • Immune system: A-8 Endoluten A-6 Vladonix® A-3 Ventfort
  • Locomotor apparatus: A-4 Sigumir A-3 Ventfort A-6 Vladonix A-21 Bonothyrk
  • Carbohydrate metabolism disorders: A-1 Suprefort A-3 Ventfort
  • Lipoprotein metabolism disorders: A-7 Svetinorm A-1 Suprefort A-3 Ventfort
  • Thyroid gland: A-2 Thyreogen A-3 Ventfort
  • Adverse factors (chemotherapy, long-term ionizing irradiation): A-6 Vladonix A-7 Svetinorm A-8 Endoluten A-20 Bonomarlot
  • Adverse factors (professional or psychoemotional stress): A-6 Vladonix A-8 Endoluten A-17 Glandokort
  • Visual organ: A-11 Visoluten A-5 Cerluten A-3 Ventfort
  • Urinary excretory system: A-6 Vladonix A-12 Chitomur A-9 Pielotax
  • Male reproductive system: A-13 Testoluten A-16 Libidon A-17 Glandokort
  • Female reproductive system: A-15 Zhenoluten A-2 Thyreogen A-3 Ventfort
  • Respiratory system: A-6 Vladonix A-19 Taxorest A-3 Ventfort
  • Intensive physical activity: A-6 Vladonix A-4 Sigumir A-3 Ventfort A-18 Gotratix A-5 Cerluten

What is a peptide bioregulator?

A peptide is a short chain of amino acids, identified by the fact that it is shorter than a protein, and so can be absorbed easily via the digestive system. Each organ or bodily function has its own unique peptide bioregulator. Peptide bioregulators have been shown to shortcut the protein synthesis process by interacting directly with cell DNA – meaning that organs can build and repair tissues easier and quicker when peptide bioregulators are active. In other words, peptides do not treat, they promote the natural repair of damaged organs.

Peptide supplements

For many years the peptide preparations were available only as medicines, in the form of injections. However some years ago Prof. Khavinson and the Russian St. Petersburg Institute of Bioregulation and Gerontology created dietary supplements that can also reduce peptide deficiency and restore peptide-protein cycle in cells. They can be divided into natural (Cytomaxes) and synthesized (Cytogens) russian peptide bioregulators.

Natural russian peptide bioregulators (Cytomaxes)

Natural russian peptide bioregulators is a group of peptides of less than 50 amino acids and with a molecular mass of less than 5 kDa, free from foreign DNA or protein substance, extracted from organs and tissues of young calves by a patented method of thorough filtering. 5 kDa is very little. The molecular mass of DNA fragments and proteinaceous infectious particles, the prions, are several times bigger than that. Therefore these natural russian peptide supplements are extremely clean products. They do not have any immunogenic or mutagenic properties.
Inside the gastrointestinal tract the natural russian peptide bioregulators break down into amino acids and di-, tri- and tetrapeptides that match the DNA in a complementary way and activate protein synthesis in the respective body system. Their performance is gentle and gradual. Their effect continues to grow even after finishing the supplementation course and lasts up to 4-6 months until the peptide-protein cycle is impaired again.

Synthesized peptide bioregulators (Cytogens)

The analysis of natural peptides was used to detect the most active peptide from a group, which was later replicated in a lab. Synthesized (Cytogens) peptide bioregulators supplement contains only one peptide molecule whereas natural one includes a group of molecules. Synthesized peptides have an immediate impact compared to natural peptides and have a faster, yet more short-lived effect (1.5-2 months). Such peptides are typically used to start the initial peptide deficiency treatment. However, it is advised to switch to natural (Cytomaxes) peptides as a follow-up course.

Both types of peptides are efficient, safe to use, have no side effects and are compatible among themselves and with other products. As for the choice between natural and synthesized russian peptides, it depends on a particular situation. However, in most cases synthesized peptides, if available, are administered prior to the use of natural peptides.

CYTOMAXES – NATURAL PEPTIDE COMPLEXES (PARAPHARMACEUTICALS)

CERLUTEN®

brain bioregulator

Correction of central nervous system functions

THYREOGEN®

thyroid gland bioregulator

Correction of endocrine system functions

VENTFORT®

vessels bioregulator

Correction of cardiovascular system functions

SIGUMIR®

cartilaginous tissue bioregulator

Correction of locomotor apparatus functions

SVETINORM®

liver bioregulator

Correction of digestive system functions

SUPREFORT®

pancreas bioregulator

VLADONIX®

thymus bioregulator

Correction of immune system functions

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