1. Vladimir Kh. Khavinson. Peptides and Ageing. // Neuroendocrinology Letters. – Vol. 23, Suppl. 3, Special Issue. – 2002. – 144 p.
2. Khavinson V.Kh., Malinin V.V. Gerontological Aspects of Genome Peptide Regulation. // Basel (Switzerland): Karger AG. – 2005. – 104 p.
3. Khavinson V.Kh. Peptidergic regulation of ageing. // SPb.: Humanistica. – 2009. – 48 p.
1. Khavinson V.Kh., Morozov V.G., Anisimov V.N. Experimental Studies of the Pineal Gland Preparation Epithalamin. // The Pineal Gland and Cancer. – Bartsch C., Bartsch H., Blask D.E., Cardinali D.P., Hrushesky W.J.M., Mecke D. (Eds.) – Springer-Verlag, Berlin, Heidelberg. – 2001. – P. 294-306.
2. Anisimov V.N., Khavinson V.Kh. Small Peptide-associated Modulation of Aging and Longevity. // Modulating Aging and Longevity. – Kluwer Academic Publishers (Printed in Great Britain). – Suresh I.S. Rattan (ed.). – 2003. – P. 279-301.
3. Vladimir N. Anisimov, Vladimir Kh. Khavinson. Pineal peptides as modulators of aging. // Aging interventions and therapies. – World Scientific. – Suresh I.S. Rattan (ed.). – 2005. – P. 127-146.
4. Khavinson V.Kh., Neroev V.V., Trofimova S.V., Osokina Yu.Yu. Unique method for restoration of retinal functions in case of different diseases. // SPb. – 2011. – 32 p.
1. Dilman V.M., Anisimov V.N., Ostroumova M.N., Khavinson V.Kh., Morozov V.G. Increase in lifespan of rats following polypeptide pineal extract treatment. // Experimental Pathology. – 1979. – Bd. 17, № 9. – P. 539-545.
2. Dilman V.M., Anisimov V.N., Ostroumova M.N., Morozov V.G., Khavinson V.Kh., Azarova M.A. Study of the Anti-Tumor Effect of Polypeptide Pineal Extract. // Oncology. – 1979. – Vol. 36, № 6. – P. 274-280.
3. Anisimov V.N., Khavinson V.Kh., Morozov V.G. Carcinogenesis and aging. IV. Effect of low-molecular-weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice. // Mechanisms of Ageing and Development. – 1982. – Vol. 19. – P. 245-258.
4. Pisarev O.A., Morozov V.G., Khavinson V.Kh., Shataeva L.K., Samsonov G.V. Isolation, physico-chemical and biological properties of the immunity polypeptide bioregulator from thymus. // Chemistry of Peptides and Proteins. – Berlin, New York. – 1982. – Vol. 1. – P. 137-142.
5. Anisimov V.N., Loktionov A.S., Khavinson V.Kh., Morozov V.G. Effect of low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age. // Mechanisms of Ageing and Development. – 1989. – Vol. 49. – P. 245-257.
6. Anisimov V.N., Bondarenko L.A., Khavinson V.Kh. The Pineal Peptides: Interaction with Indoles and the Role in Aging and Cancer. // Neuroendocrinology: New Frontiers. – London, Tübingen. – 1990. – P. 317-325.
7. Anisimov V.N., Bondarenko L.A., Khavinson V.Kh. Effect of Pineal Peptide Preparation (Epithalamin) on Life Span and Pineal and Serum Melatonin Level in Old Rats. // Annals of New York Academy of Sciences. – 1992. – Vol. 673. – P. 53-57.
8. Anisimov V.N., Khavinson V.Kh., Morozov V.G. Twenty Years of Study on Effects of Pineal Peptide Preparation: Epithalamin in Experimental Gerontology and Oncology. // Annals of the New York Academy of Sciences. – 1994. – Vol. 719. – P. 483-493.
9. Alexandrov V.A., Bespalov V.G., Morozov V.G., Khavinson V.Kh., Anisimov V.N. Study of the post-natal effects of chemopreventive agents on ethylnitrosourea-induced transplacental carcinogenesis in rats. II. Influence of low-molecular-weight polypeptide factors from the thymus, pineal gland, bone marrow, anterior hypothalamus, brain cortex and brain white substance. // Carcinogenesis. – 1996. – Vol. 17, № 8. – P. 1931-1934.
10. Anisimov V.N., Mylnikov S.V., Oparina T.I., Khavinson V.Kh. Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogaster. // Mechanisms of Ageing and Development. – 1997. – Vol. 97. – P. 81-91.
11. Morozov V.G., Khavinson V.Kh. Natural and synthetic thymic peptides as therapeutics for immune dysfunction. // Int. J. Immunopharmacology. – 1997. – Vol. 19, № 9/10. – P. 501-505.
12. Anisimov V.N., Mylnikov S.V., Khavinson V.Kh. Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats. // Mechanisms of Ageing and Development. – 1998. – Vol. 103. – P. 123-132.
13. Khavinson V.Kh., Solovieva D.V. New approach to the prophylaxis and treatment of age-related pathology. // Romanian Journal of Gerontology and Geriatrics. – 1998. – Vol. 20, № 1. – P. 28-34.
14. Anisimov V.N., Khavinson V.Kh., Morozov V.G. Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats. // Biogerontology. – 2000. – Vol. 1. – P. 55-59.
15. Khavinson V.Kh., Anisimov V.N., Zavarzina N.Yu., Zabezhinskii M.A., Zimina O.A., Popovich I.G., Shtylik A.V., Malinin V.V., Morozov V.G. Effect of Vilon on Biological Age and Lifespan in Mice. // Bulletin of Experimental Biology and Medicine. – 2000. – Vol. 130, № 7. – P. 687–690.
16. Khavinson V.Kh., Izmailov D.M., Obukhova L.K., Malinin V.V. Effect of epitalon on the lifespan increase in Drosophila melanogaster. // Mechanisms of Ageing and Development. – 2000. – Vol. 120. – P. 141-149.
17. Khavinson V.Kh., Kvetnoii I.M. Peptide Bioregulators Inhibit Apoptosis. // Bulletin of Experimental Biology and Medicine. – 2000. – Vol. 130, № 12. – P. 1175-1176.
18. Khavinson V.Kh., Morozov V.G., Malinin V.V., Kazakova T.B., Korneva E.A. Effect of Peptide Lys-Glu on Interleukin-2 Gene Expression in Lymphocytes. // Bulletin of Experimental Biology and Medicine. – 2000. – Vol. 130, № 9. – P. 898-899.
19. Khavinson V.Kh., Myl’nikov S.V. Effect of Epithalone on the Age-Specific Changes in the Time Course of Lipid Peroxidation in Drosophila melanogaster. // Bulletin of Experimental Biology and Medicine. – 2000. – Vol. 130, № 11. – P. 1116-1119.
20. Khavinson V.Kh., Myl’nikov S.V. Effect of Pineal Tetrapeptide on Antioxidant Defense in Drosophila melanogaster. // Bulletin of Experimental Biology and Medicine. – 2000. – Vol. 129, № 4. – P. 355-356.
21. Khavinson V.Kh., Popuchiev V.V., Kvetnoii I.M., Yuzhakov V.V., Kotlova L.N. Regulating Effect of Epithalone on Gastric Endocrine Cells in Pinealectomized Rats. // Bulletin of Experimental Biology and Medicine. – 2000. – Vol. 130, № 12. – P. 1169-1171.
22. Kvetnoy I.M., Reiter R.J., Khavinson V.Kh. Claude Bernard was right: hormones may be produced by “non-endocrine” cells. // Neuroendocrinology Letters. – 2000. – Vol. 21, № 3. – P. 173-174.
23. Turchaninova L.N., Kolosova L.I., Malinin V.V., Moiseeva A.B., Nozdrachev A.D., Khavinson V.Kh. Effect of Tetrapeptide Cortagen on Regeneration of Sciatic Nerve. // Bulletin of Experimental Biology and Medicine. – 2000. – Vol. 130, № 12. – P. 1172-1174.
24. Anisimov V.N., Arutjunyan A.V., Khavinson V.Kh. Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals. // Neuroendocrinology Letters. – 2001. – Vol. 22, № 1. – P. 9-18.
25. Anisimov V.N., Khavinson V.Kh., Mikhalski A.I., Yashin A.I. Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. // Mechanisms of Ageing and Development. – 2001. – Vol. 122, № 1. – P. 41-68.
26. Khavinson V.Kh. Tissue-Specific Effects of Peptides. // Bulletin of Experimental Biology and Medicine. – 2001. – Vol. 132, № 2. – P. 807-808.
27. Khavinson V., Goncharova N., Lapin B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. // Neuroendocrinology Letters. – 2001. – Vol. 22, № 4. – P. 251-254.
28. Khavinson V.Kh., Konovalov S.S., Yuzhakov V.V., Popuchiev V.V., Kvetnoi I.M. Modulating Effects of Epithalamin and Epithalon on the Functional Morphology of the Spleen in Old Pinealectomized Rats. // Bulletin of Experimental Biology and Medicine. – 2001. – Vol. 132, № 5. – P. 1116-1120.
29. Khavinson V.Kh., Myl’nikov S.V., Oparina T.I., Arutyunyan A.V. Effects of Peptides on Generation of Reactive Oxygen Species in Subcellular Fractions of Drosophila melanogaster. // Bulletin of Experimental Biology and Medicine. – 2001. – Vol. 132, № 1. – P. 682-685.
30. Khavinson V.Kh., Timofeeva N.M., Malinin V.V., Egorova V.V., Nikitina A.A. Effect of the Dipeptide Vilon on Activity of Digestive Enzyme in Rats of Various Ages. // Bulletin of Experimental Biology and Medicine. – 2001. – Vol. 131, № 6. – P. 583-585.
31. Khavinson V.Kh., Yakovleva N.D., Popuchiev V.V., Kvetnoi I.M., Manokhina R.P. Reparative Effect of Epithalon on Pineal Gland Ultrastructure in g-Irradiated Rats. // Bulletin of Experimental Biology and Medicine. – 2001. – Vol. 131, № 1. – P. 81-85.
32. Khavinson V.Kh., Yuzhakov V.V., Kvetnoi I.M., Malinin V.V., Popuchiev V.V., Fomina N.K. Immunohistochemical and Morphometric Analysis of Effects of Vilon and Epithalon on Functional Morphology of Radiosensitive Organs. // Bulletin of Experimental Biology and Medicine. – 2001. – Vol. 131, № 3. – P. 285-292.
33. Pliss G.B., Mel’nikov A.S., Malinin V.V., Khavinson V.Kh. Inhibitory Effect of Peptide Vilon on the Development of Induced Rat Urinary Bladder Tumors in Rats. // Bulletin of Experimental Biology and Medicine. – 2001. – Vol. 131, № 6. – P. 558-560.
34. Anisimov S.V., Bokheler K.R., Khavinson V.Kh., Anisimov V.N. Studies of the Effects of Vilon and Epithalon on Gene Expression in Mouse Heart using DNA-Microarray Technology. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 133, № 3. – P. 293-299.
35. Anisimov V.N., Khavinson V.Kh., Alimova I.N., Provintsiali M., Manchini R., Francheski K. Epithalon Inhibits Tumor Growth and Expression of HER-2/neu Oncogene in Breast Tumors in Transgenic Mice Characterized by Accelerated Aging. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 133, № 2. – P. 167-170.
36. Anisimov V.N., Khavinson V.Kh., Alimova I.N., Semchenko A.V., Yashin A.I. Epithalon Decelerates Aging and Suppresses Development of Breast Adenocarcinomas in Transgenic HER-2/neu Mice. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 134, № 2. – P. 187-190.
37. Anisimov V.N., Khavinson V.Kh., Popovich I.G., Zabezhinski M.A. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. // Cancer Letters. – 2002. – Vol. 183. – P. 1-8.
38. Anisimov V.N., Khavinson V.Kh., Provinciali M., Alimova I.N., Baturin D.A., Popovich I.G., Zabezhinski M.A., Imyanitov E.N., Mancini R., Franceschi C. Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/NEU transgenic mice. // Internaional Journal of Cancer. – 2002. – Vol. 101. – P. 7-10.
39. Goncharova N.D., Lapin B.A., Khavinson V.Kh. Age-Associated Endocrine Dysfunctions and Approaches to Their Correction. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 134, № 5. – P. 417-421.
40. Khavinson V.Kh., Egorova V.V., Timofeeva N.M., Malinin V.V., Gordova L.A., Gromova L.V. Effect of Vilon and Epithalon on Glucose and Glycine Absorption in Various Regions of Small Intestine in Aged Rats. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 133, № 5. – P. 494-496.
41. Khavinson V.Kh., Korneva E.A., Malinin V.V., Rybakina E.G., Pivanovich I.Yu., Shanin S.N. Effect of Epitalon on Interleukin-1ß Signal Transduction and the Reaction of Thymocyte Blast Transformation Under Stress. // Neuroendocrinology Letters. – 2002. – Vol. 23, № 5/6. – P. 411-416.
42. Khavinson V.Kh., Lezhava T.A., Monaselidze J.G., Dzhokhadze T.A., Dvalishvili N.A., Bablishvili N.K., Ryadnova I.Yu. Effects of Livagen Peptide on Chromatin Activation in Lymphocytes from Old People. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 134, № 4. – P. 389-392.
43. Khavinson V.Kh., Malinin V.V. Mechanisms Underlying Geroprotective Effects of Peptides. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 133, № 1. – P. 1-5.
44. Khavinson V.Kh., Malinin V.V., Timofeeva N.M., Egorova V.V., Nikitina A.A. Effects of Epithalon on Activities Gastrointestinal Enzymes in Young and Old Rats. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 133, № 3. – P. 290-292.
45. Khavinson V.Kh., Malinin V.V., Trofimova S.V., Zemchikhina V.N. Inductive Activity of Retinal Peptides. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 134, № 5. – P. 482-484.
46. Khavinson V.Kh., Razumovskii M.I., Trofimova S.V., Grigor’yan R.A., Chaban T.V., Oleinik T.L., Razumovskaya A.M. Effect of Epithalon on Age-Specific Changes in the Retina in Rats with Hereditary Pigmentary Dystrophy. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 133, № 1. – P. 87-89.
47. Khavinson V., Razumovsky M., Trofimova S., Grigorian R., Razumovskaya A. Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. // Neuroendocrinology Letters. – 2002. – Vol. 23, № 4. – P. 365-368.
48. Khavinson V.Kh., Rybakina E.G., Malinin V.V., Pivanovich I.Yu., Shanin S.N., Korneva E.A. Effects of Short Peptides on Thymocyte Blast Transformation and Signal Transduction along the Sphingomyelin Pathway. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 133, № 5. – P. 497-499.
49. Khavinson V.Kh., Timofeeva N.M., Malinin V.V., Gordova L.A., Nikitina A.A. Effect of Vilon and Epithalon on Activity of Enzymes in Epithelial and Subepithelial Layers in Small Intestine of Old Rats. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 134, № 6. – P. 562-564.
50. Khlystova Z.S., Kalinina I.I., Khavinson V.Kh. Thymic Hormones in Human Fetal Skin Epidermis. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 133, № 2. – P. 196-198.
51. Rosenfeld S.V., Togo E.F., Mikheev V.S., Popovich I.G., Zabezhinskii A.M., Khavinson V.Kh., Anisimov V.N. Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice. // Bulletin of Experimental Biology and Medicine. – 2002. – Vol. 133, № 3. – P. 274-276.
52. Sibarov D.A., Kovalenko R.I., Malinin V.V., Khavinson V.Kh. Epitalon influences pineal secretion in stress-exposed rats in the daytime. // Neuroendocrinology Letters. – 2002. – Vol. 23, № 5/6. – P. 452-454.
53. Anisimov V.N., Khavinson V.Kh., Popovich I.G., Zabezhinski M.A., Alimova I.N., Rosenfeld S.V., Zavarzina N.Yu., Semenchenko A.V., Yashin A.I. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. // Biogerontology. – 2003. – № 4. – P. 193-202.
54. Khavinson V.Kh., Bondarev I.E., Butyugov A.A. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. // Bulletin of Experimental Biology and Medicine. – 2003. – Vol. 135, № 6. – P. 590-592.
55. Khavinson V.Kh, Lezhava T.A., Monaselidze J.R., Jokhadze T.A., Dvalis N.A., Bablishvili N.K., Trofimova S.V. Peptide Epitalon activates chromatin at the old age. // Neuroendocrinology Letters. – 2003. – Vol. 24, № 5 – P. 329-333.
56. Khavinson V.Kh., Morozov V.G. Peptides of pineal gland and thymus prolong human life. // Neuroendocrinology Letters. – 2003. – Vol. 24, № 3/4. – P. 233-240.
57. Khavinson V.Kh., Razumovsky M.I., Trofimova S.V., Razumovskaya A.M. Retinoprotective Effect of Epithalon in Campbell Rats of Various Ages. // Bulletin of Experimental Biology and Medicine. – 2003. – Vol. 135, № 5. – P. 495-498.
58. Khavinson V.Kh., Shataeva L.K., Chernova A.A. Effect of Regulatory Peptides on Gene Transcription. // Bulletin of Experimental Biology and Medicine. – 2003. – Vol. 136, № 3. – P. 288-290.
59. Khavinson V.Kh., Zemchikhina V.N., Trofimova S.V., Malinin V.V. Effect of Peptides on Proliferative Activity of Retinal and Pigmented Epithelial Cells. // Bulletin of Experimental Biology and Medicine. – 2003. – Vol. 135, № 6. – P. 597-599.
60. Kossoy G., Zandbank J., Tendler E., Anisimov V., Khavinson V., Popovich I., Zabezhinski M., Zusman I., Ben-Hur H. Epitalon and colon carcinogenesis in rats: Proliferative activity and apoptosis in colon tumors and mucosa. // International Journal of Molecular Medicine. – 2003. – Vol. 12, № 4. – P. 473-477.
61. Ryzhak G.A., Nekrasov P.A., Kiselev O.I., Khavinson V.Kh. Study of Protein Components of Natural Peptide Regulators. // Bulletin of Experimental Biology and Medicine. – 2003. – Vol. 135, № 1. – P. 52-54.
62. Tutel’yan V.A., Khavinson V.Kh., Malinin V.V. Physiological Role of Short Peptides in Nutrition. // Bulletin of Experimental Biology and Medicine. – 2003. – Vol. 135, № 1. – P. 1-5.
63. Anisimov S.V., Boheler K.R., Khavinson V.Kh., Anisimov V.N. Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray. // Neuroendocrinology Letters. – 2004. – Vol. 25, № 1/2. – P. 87-93.
64. Anisimov S.V., Khavinson V.Kh, Anisimov V.N. Effect of Melatonin and Tetrapeptide on Gene Expression in Mouse Brain. // Bulletin of Experimental Biology and Medicine. – 2004. – Vol. 137, № 5. – P. 504-509.
65. Goncharova N.D., Vengerin A.A., Khavinson V.Kh, Lapin B.A. Peptide Correction of Age-Related Hormonal Dysfunction of the Pancreas in Monkeys. // Bulletin of Experimental Biology and Medicine. – 2004. – Vol. 138, № 7. – P. 80-83.
66. Khavinson V.Kh, Bondarev I.E, Butyugov A.A., Smirnova T.D. Peptide Promotes Overcoming of the Division Limit in Human Somatic Cell. // Bulletin of Experimental Biology and Medicine. – 2004. – Vol. 137, № 5. – P. 613-616.
67. Khavinson V.Kh, Lezhava T.A., Malinin V.V. Effects of Short Peptides on Lymphocyte Chromatin in Senile Subjects. // Bulletin of Experimental Biology and Medicine. – 2004. – Vol. 137, № 1. – P. 78-81.
68. Korkushko O.V., Khavinson V.Kh., Shatilo V.B., Magdich L.V. Effect of Peptide Preparation Epithalamin on Circadian Rhythm of Epiphyseal Melatonin-Producing Function in Elderly People. // Bulletin of Experimental Biology and Medicine. – 2004. – Vol. 137, № 4. – P. 389-391.
69. Labunets I.F., Butenko G.M., Khavinson V.Kh. Effects of Bioactive Factors of the Pineal Gland on Thymus Function and Cell Composition of the Bone Marrow and Spleen in Mice of Different Age. // Bulletin of Experimental Biology and Medicine. – 2004. – Vol. 137, № 5. – P. 620-622.
70. Labunets I.F., Butenko G.M., Magdich L.V., Korkushko O.V., Khavinson V.Kh., Shatilo V.B. Effect of Epithalamin on Circadian Relationship between the Endocrine Function of the Thymus and Melatonin-Producing Function of the Pineal Gland in Elderly People. // Bulletin of Experimental Biology and Medicine. – 2004. – Vol. 137, № 5. – P. 617-619.
71. Lezhava T., Khavinson V., Monaselidze J., Jokhadze T., Dvalishvili N., Bablishvili N., Barbakadze S. Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people. // Biogerontology. – 2004. – № 5. – P. 73-79.
72. Raikhlin N.T., Bukaeva I.A., Smirnova E.A., Yarilin A.A., Sharova N.I., Mitneva M.M., Khavinson V.Kh., Polyakova V.O., Trofimov A.V., Kvetnoi I.M. Expression of Argyrophilic Proteins in the Nucleolar Organizer Regions of Human Thymocytes and Thymic Epitheliocytes under Conditions of Coculturing with Vilon and Epithalon Peptides. // Bulletin of Experimental Biology and Medicine. – 2004. – Vol. 137, № 6. – P. 588-591.
73. Goncharova N.D., Vengerin A.A., Khavinson V.Kh., Lapin B.A. Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas. // Experimental Gerontology. – 2005. – Vol. 40. – P. 51-57.
74. Khavinson V.Kh. Effect of Tetrapeptide on Insulin Biosynthesis in Rats with Alloxan-Induced Diabetes. // Bulletin of Experimental Biology and Medicine. – 2005. – Vol. 140, № 4. – P. 452-454.
75. Khavinson V., Shataeva L., Chernova A. DNA double-helix binds regulatory peptides similarly to transcription factors. // Neuroendocrinology Letters. – 2005. – Vol. 26, № 3. – P. 237-241.
76. Barabanova S.V., Artyukhina Z.E., Kazakova T.B., Khavinson V.Kh., Malinin V.V., Korneva E.A. Interleukin-2 Concentration in Hypothalamic Structures of Rats Receiving Peptides during Mild Stress. // Bulletin of Experimental Biology and Medicine. – 2006. – Vol. 141, № 4. – P. 390-393.
77. Khavinson V.Kh., Solovyov A.Yu., Shataeva L.K. Molecular Mechanism of Interaction between Oligopeptides and Double-Stranded DNA. // Bulletin of Experimental Biology and Medicine. – 2006. – Vol. 141, № 4. – P. 457-461.
78. Korkushko O.V., Khavinson V.Kh., Shatilo V.B., Antonyuk-Shcheglova I.A. Geroprotective Effect of Epithalamine (Pineal Gland Peptide Preparation) in Elderly Subjects with Accelerated Aging. // Bulletin of Experimental Biology and Medicine. – 2006. – Vol. 142, № 3. – P. 356-359.
79. Khavinson V.Kh., Gavrisheva N.A., Malinin V.V., Chefu S.G., Trofimov E.L. Effect of Pancragen on Blood Glucose Level, Capillary Permeability and Adhesion in Rats with Experimental Diabetes Mellitus. // Bulletin of Experimental Biology and Medicine. – 2007. – Vol. 144, № 4. – P. 559-562.
80. Kozina L.S., Arutjunyan A.V., Khavinson V.Kh. Antioxidant properties of geroprotective peptides of the pineal gland. // Archives of Gerontology and Geriatrics. – 2007. – Suppl. 1. – P. 213-216.
81. Vinogradova I.A., Bukalev A.V., Zabezhinski M.A., Semenchenko A.V., Khavinson V.Kh., Anisimov V.N. Effect of Ala-Glu-Asp-Gly Peptide on Life Span and Development of Spontaneous Tumors in Female Rats Exposed to Different Illumination Regimes. // Bulletin of Experimental Biology and Medicine. – 2007. – Vol. 144, № 6. – P. 825-830.
82. Khavinson V.Kh., Solovyov A.Yu., Shataeva L.K. Melting of DNA Double Strand after Binding to Geroprotective Tetrapeptide. // Bulletin of Experimental Biology and Medicine. – 2008. – Vol. 146, № 5. – P. 624-626.
83. Vinogradova I.A., Bukalev A.V., Zabezhinski M.A., Semenchenko A.V., Khavinson V.Kh., Anisimov V.N. Geroprotective Effect of Ala-Glu-Asp-Gly Peptide in Male Rats Exposed to Different Illumination. // Bulletin of Experimental Biology and Medicine. – 2008. – Vol. 145, № 4. – P. 472-477.
84. Khavinson V.Kh., Anisimov V.N. Peptide Regulation of Aging: 35-Year Research Experience. // Bulletin of Experimental Biology and Medicine. – 2009. – Vol. 148, № 1. – P. 94-98.
85. Anisimov V.N., Khavinson V.Kh. Peptide bioregulation of aging: results and prospects. // Biogerontology. – 2010. – Vol. 11, № 2. – P. 139-149.
86. Khavinson V.Kh., Gapparov M.M.-G., Sharanova N.E., Vasilyev A.V., Ryzhak G.A. Study of Biological Activity of Lys-Glu-Asp-Trp-NH2 Endogenous Tetrapeptide. // Bulletin of Experimental Biology and Medicine. – 2010. – Vol. 149, № 3. – P. 351-353.
87. Fedoreyeva L.I., Kireev I.I., Khavinson V.Kh., Vanyushin B.F. Penetration of Short Fluorescence-Labeled Peptides into the Nucleus in HeLa Cells and in vitro Specific Interaction of the Peptides with Deoxyribooligonucleotides and DNA. // Biochemistry. – 2011. – Vol. 76, № 11. – P. 1210-1219.
88. Khavinson V.Kh., Fedoreeva L.I., Vanyushin B.F. Short Peptides Modulate the Effect of Endonucleases of Wheat Seedling. // Doklady Biochemistry and Biophysics. – 2011. – Vol. 437, № 1. – P. 64-67.
89. Khavinson V.Kh., Fedoreeva L.I., Vanyushin B.F. Site-Specific Binding of Short Peptides with DNA Modulated Eukaryotic Endonuclease Activity. // Bulletin of Experimental Biology and Medicine. – 2011. – Vol. 151, № 1. – P. 66-70.
90. Khavinson V.Kh., Linkova N.S., Chalisova N.I., Dudkov A.V., Koncevaya E.A. Effect of Short Peptides on Expression of Signaling Molecules in Organotypic Pineal Cell Culture. // Bulletin of Experimental Biology and Medicine (Cell Technologies in Biology and Medicine). – 2011. – № 3, November. – P. 138-141.
91. Khavinson V.Kh., Linkova N.S., Polyakova V.O., Dudkov A.V., Kvetnoy I.M. Age-Specific Dynamics of Human Thymus Immune Cell Differentiation. // Bulletin of Experimental Biology and Medicine. – 2011. – Vol. 151, № 5. – P. 631-633.
92. Khavinson V.Kh., Lin’kova N.S., Trofimov A.V., Polyakova V.O., Sevost’yanova N.N., Kvetnoy I.M. Morphofunctional Fundamentals for Peptide Regulation of Aging. // Biology Bulletin Reviews. – 2011. – Vol. 1, № 4. – P. 390-394.
93. Khavinson V.Kh., Nikolsky I.S., Nikolskaya V.V., Zubov D.A., Galickaya S.N., Taranuha L.I., Semenova Ya.-M.A., Lisica N.A., Linkova N.S., Butenko G.M. Effect of Tripeptides on Lymphoid and Stem Cells. // Bulletin of Experimental Biology and Medicine. – 2011. – Vol. 151, № 6. – P. 722-725.
94. Khavinson V.Kh., Polyakova V.O., Linkova N.S., Dudkov A.V., Kvetnoy I.M. Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis. // Journal of Amino Acids. – 2011. – Vol. 2011. – P. 1-5.
95. Khavinson V., Ribakova Y., Kulebiakin K., Vladychenskaya E., Kozina L., Arutjunyan A., Boldyrev A. Pinealon Increases Cell Viability by Suppression of Free Radical Levels and Activating Proliferative Processes. // Rejuvenation Research. – 2011. – Vol. 14, № 5. – P. 535-541.
96. Korkushko O.V., Khavinson V.Kh., Shatilo V.B., Antonyk-Sheglova I.A. Peptide Geroprotector from the Pineal Gland Inhibits Rapid Aging of Elderly People: Results of 15-Year Follow-Up. // Bulletin of Experimental Biology and Medicine. – 2011. – Vol. 151, № 3. – P. 366-369.
97. Korkushko O.V., Khavinson V.Kh., Shatilo V.B., Antonyk-Sheglova I.A., Bondarenko E.V. Prospects of Using Pancragen for Correction of Metabolic Disorders in Elderly People. // Bulletin of Experimental Biology and Medicine. – 2011. – Vol. 151, № 4. – P. 454-456.
98. Linkova N.S., Khavinson V.Kh., Chalisova N.I., Katanugina A.S., Koncevaya E.A. Peptidergic Stimulation of Differentiation of Pineal Immune Cells. // Bulletin of Experimental Biology and Medicine (Cell Technologies in Biology and Medicine). – 2011. – № 3, November. – P. 124-127.
99. Lin’kova N.S., Polyakova V.O., Trofimov A.V., Kvetnoy I.M., Khavinson V.Kh. Peptidergic Regulation of Thymocyte Differentiation, Proliferation, and Apoptosis during Aging of the Thymus. // Bulletin of Experimental Biology and Medicine. – 2011. – Vol. 151, № 2. – P. 239-242.
100. Monaselidze J.R., Khavinson V.Kh., Gorgoshidze M.Z., Khachidze D.G., Lomidze E.M., Jokhadze T.A., Lezhava T.A. Effect of the Peptide Bronchogen (Ala-Asp-Glu-Leu) on DNA Thermostability. // Bulletin of Experimental Biology and Medicine. – 2011. – Vol. 150, № 3. – P. 375-377.
101. Polyakova V.O., Linkova N.S., Kvetnoy I.M., Khavinson V.Kh. Functional Unity of the Thymus and Pineal Gland and Study of the Mechanisms of Aging. // Bulletin of Experimental Biology and Medicine. – 2011. – Vol. 151, № 5. – P. 627-630.
102. Solov’ev A.Yu., Morozova P.Yu., Chernova I.A., Chalisova N.I., Shataeva L.K., Zakutskii A.N., Khavinson V.Kh. Extraction and Activity of Regulatory Peptide from Sea Urchin Eggs. // Pharmaceutical Chemistry Journal. – 2011. – Vol. 44, № 11. – P. 601-603.
103. Arutjunyan A., Kozina L., Stvolinskiy S., Bulygina Y., Mashkina A., Khavinson V. Pinealon prorects the rat offspring from prenatal hyperhomocysteinemia. // International Journal of Clinical Experimental Medicine. – 2012. – Vol. 5, № 2. – P. 179-185.
104. Chalisova N.I., Lopatina N.G., Kamishev N.G., Linkova N.S., Koncevaya E.A., Dudkov A.V., Kozina L.S., Khavinson V.Kh., Titkov Yu.S. Effect of Tripeptide Lys-Glu-Asp on Physiological Activity of Neuroimmunoendocrine System Cells. // Bulletin of Experimental Biology and Medicine (Cell Technologies in Biology and Medicine). – 2012. – № 2, August. – P. 569-572.
105. Khavinson V.Kh., Lin’kova N.S., Dudkov A.V., Polyakova V.O., Kvetnoi I.M. Peptidergic Regulation of Expression of Genes Encoding Antioxidant and Anti-Inflammatory Proteins. // Bulletin of Experimental Biology and Medicine. – 2012. – Vol. 152, № 5. – P. 615-618.
106. Khavinson V.Kh., Linkova N.S., Kvetnoy I.M., Kvetnaia T.V., Polyakova V.O., Korf H.-W. Molecular Cellular Mechanisms of Peptide Regulation of Melatonin Synthesis in Pinealocyte Culture. // Bulletin of Experimental Biology and Medicine. – 2012. – Vol. 153, № 2. – P. 255-258.
107. Khavinson V.Kh., Linkova N.S., Polyakova V.O., Kheifets O.V., Tarnovskaya S.I., Kvetnoi I.M. Peptides Tissue-Specifically Stimulate Cell Differentiation during Their Aging. // Bulletin of Experimental Biology and Medicine (Cell Technologies in Biology and Medicine). – 2012. – № 1, May. – P. 148-151.
108. Khavinson V.Kh., Lin’kova N.S., Polyakova V.O., Kvetnoi I.M., Benberin V.V., D’yakonov M.M., Titkov Yu.S. Tetrapeptide H-Ala-Glu-Asp-Arg-OH Stimulates Expression of Cytoskeletal and Nuclear Matrix Proteins. // Bulletin of Experimental Biology and Medicine (Cell Technologies in Biology and Medicine). – 2012. – № 2, August. – P. 559-562.
109. Khavinson V.Kh., Linkova N.S., Pronyaeva V.E., Chalisova N.I., Koncevaya E.A., Polyakova V.O., Kvetnaya T.V., Kvetnoy I.M., Yakovlev G.M. A Method of Creating a Cell Monolayer Based on Organotypic Culture for Screening of Physiologically Active Substances. // Bulletin of Experimental Biology and Medicine. – 2012. – Vol. 153 № 5 – P. 795-799.
110. Khavinson V.Kh., Malinin V.V., Vanyushin B.F. Role of Peptides in Epigenetic Regulation of Gene Activities in Ontogeny. // Bulletin of Experimental Biology and Medicine. – 2012. – Vol. 152 № 4 – P. 470-474.
111. Khavinson V.Kh., Solov’ev A.Yu., Zhilinskii D.V., Shataeva L.K., Vanyushin B.F. Epigenetic Aspects of Peptide-Mediated Regulation of Aging. // Advances in Gerontology. – 2012. – Vol. 2, № 4. – P. 277-286.
112. Linkova N.S., Katanugina A.S., Khavinson V.Kh. Expression of AIF and CGRP Markers in Epiphysis and Thymus during Aging. // Advances in Gerontology. – 2012. – Vol. 2, № 3. – P. 230-233.
113. Zamorskii I.I., Sopova I.Yu., Khavinson V.Kh. Effect of Melatonin and Epithalamin on the Content of Protein and Lipid Peroxidation Products in Rat Cortex and Hippocampus under Conditions of Acute Hypoxia. // Bulletin of Experimental Biology and Medicine. – 2012. – Vol. 154 № 1 – P. 51-53.
114. Berrut G., Andrieu S., Araujo de Carvalho I., Baeyens J.P., Bergman H., Cassim B., Cerreta F., Cesari M., Cha H.B., Chen L.K., Cherubini A., Chou M.Y., Cruz-Jentoft A.J., L.de Decker, Du P., Forette B., Forette F., Franco A., Guimaraes R., Gutierrez-Robledo L.M., Jauregui J., Khavinson V., Lee W.J., Peng L.N., Perret-Guillaume C., Petrovic M., Retornaz F., Rockwood K., Rodriguez-Manas L., Sieber C., Spatharakis G., Theou O., Topinkova E., Vellas B., Benetos A. Promoting access to innovation for frail old persons. // The Journal of Nutrition, Health & Aging. – 2013. – Vol. 17, № 8. – P. 688-693.
115. Calisova N.I., Konsevaya N.E., Linkova N.S., Pronyaeva V.E., Chervyakova N.A., Umnov R.S., Benberin V.V., Khavinson V.Kh. Biological Activity of Amino Acids in Organotypic Tissue Cultures. // Bulletin of Experimental Biology and Medicine (Cell Technologies in Biology and Medicine). – 2013. – Vol. 155, № 4. – P. 581-585.
116. Fedoreeva L.I., Smirnova T.A., Kolomijtseva G.Ya., Khavinson V.Kh., Vanyushin B.F. Interaction of Short Peptides with FITC-Labeled Wheat Histones and Their Complexes with Deoxyribooligonucleotides. // Biochemistry (Moscow). – 2013. – Vol. 78, № 2. – P. 166-175.
117. Khavinson V.Kh., Durnova A.O., Polyakova V.O.
]]>Russian peptide technology was founded during the Cold War years- to help protect elements of the then Soviet forces.
Today Professor Vladimir Khavinson is the President of the European Academy of Gerontology and Geriatrics, but in the 1980’s he was a Colonel in the Soviet Union military medical corps. At the time, he and his team were approached by Kremlin officials, they wanted them to find a way to protect their troops from a myriad of problems; issues such as radiation for submariners in nuclear submarines to troops that may be blinded from known, (but thankfully unused) new weapons such as battlefield lasers.
What their secret research uncovered - that was used for two decades on many thousands of men and women - was a remarkable link between short chain peptides and DNA.
Now their published research is in the open and it identifies that each organ / gland / tissue uses a highly specific short chain peptide to act as a ‘short cut’ to initiate protein synthesis. These peptides can be found in food and unlike proteins they can enter the blood through the stomach. Through a comprehensive list of patents and even copyrighted PowerPoint slides, the Russian research group are showing that each of the concentrated peptide bioregulators so far examined interact with particular strands of DNA - effectively and very specifically activating repair and regenerative processes.
This is a remarkable story since what we are describing here are individualised gene switches and since they have been tested for many years on thousands of individuals, without report of any serious side effects or contraindications to date, they could be set to ‘out do’ stem cells. Why? Because this peptide therapy is relatively cheap, highly specific, can be taken orally and doesn’t require any suppression of the immune system to operate fully.
Professor Khavinson and his award winning team at the St Petersburg Institute of Biogerontology have discovered that each organ / gland has a biological reserve and despite the origin of the tissue they have studied, incredibly each one is always set at 42%
What is a peptide bioregulator?
A peptide is a short chain of amino acids, identified by the fact that it is shorter than a protein, and so can be absorbed easily via the digestive system. Each organ or bodily function has its own unique peptide bioregulator. Peptide bioregulators have been shown to shortcut the protein synthesis process by interacting directly with cell DNA – meaning that organs can build and repair tissues easier and quicker when peptide bioregulators are active. In other words, peptides do not treat, they promote the natural repair of damaged organs.
Peptide supplements
For many years the peptide preparations were available only as medicines, in the form of injections. However some years ago Prof. Khavinson and the Russian St. Petersburg Institute of Bioregulation and Gerontology created dietary supplements that can also reduce peptide deficiency and restore peptide-protein cycle in cells. They can be divided into natural (Cytomaxes) and synthesized (Cytogens) russian peptide bioregulators.
Natural russian peptide bioregulators (Cytomaxes)
Natural russian peptide bioregulators is a group of peptides of less than 50 amino acids and with a molecular mass of less than 5 kDa, free from foreign DNA or protein substance, extracted from organs and tissues of young calves by a patented method of thorough filtering. 5 kDa is very little. The molecular mass of DNA fragments and proteinaceous infectious particles, the prions, are several times bigger than that. Therefore these natural russian peptide supplements are extremely clean products. They do not have any immunogenic or mutagenic properties.
Inside the gastrointestinal tract the natural russian peptide bioregulators break down into amino acids and di-, tri- and tetrapeptides that match the DNA in a complementary way and activate protein synthesis in the respective body system. Their performance is gentle and gradual. Their effect continues to grow even after finishing the supplementation course and lasts up to 4-6 months until the peptide-protein cycle is impaired again.
Synthesized peptide bioregulators (Cytogens)
The analysis of natural peptides was used to detect the most active peptide from a group, which was later replicated in a lab. Synthesized (Cytogens) peptide bioregulators supplement contains only one peptide molecule whereas natural one includes a group of molecules. Synthesized peptides have an immediate impact compared to natural peptides and have a faster, yet more short-lived effect (1.5-2 months). Such peptides are typically used to start the initial peptide deficiency treatment. However, it is advised to switch to natural (Cytomaxes) peptides as a follow-up course.
Both types of peptides are efficient, safe to use, have no side effects and are compatible among themselves and with other products. As for the choice between natural and synthesized russian peptides, it depends on a particular situation. However, in most cases synthesized peptides, if available, are administered prior to the use of natural peptides.
What is a peptide bioregulator?
A peptide is a short chain of amino acids, identified by the fact that it is shorter than a protein, and so can be absorbed easily via the digestive system. Each organ or bodily function has its own unique peptide bioregulator.
Peptide bioregulators have been shown to shortcut the protein synthesis process by interacting directly with cell DNA – meaning that organs can build and repair tissues easier and quicker when peptide bioregulators are active.
What combination of peptides would be best to consider for the elderly in general?
Glandokort® - adrenal peptide, Vladonix® -thymus peptide and Ventfort® - blood vessels peptide.
Would there be a difference between dosing for men and women?
Not particularly, the dosing is more related to need than sex or body weight
Is it best to include the blood vessel peptide in all combinations used?
Yes it is recommended, the blood vessel peptide is known as Ventfort®
What is the typical dosing regimen for the peptides in general?
Two capsules a day for 10-days - a total of 20 capsules equivalent to one pack - for general support this can be repeated again in 6-months’ time, if the need is greater then it can be repeated again in 2 to 3 months’ time, if the need is felt to be great then typically the regimen is repeated every month.
How many peptide complexes can I take at the same time?
You can combine up to 5 peptide complexes at the same time.
What are the side effects?
15 million people have undergone the peptide treatment for 30 years and no side effects have been found. The fact is that peptides in animals and humans are identical and our body sees them as its own. Peptides only normalize the protein synthesis and they are not able to overstimulate it.
Are there any contraindications?
Individual intolerance to the components, pregnancy and breastfeeding.
Can I take peptides with other supplements too?
Yes, you can.
How can I be sure that peptides have an actual effect on me?
Sometimes it can be hard to notice changes subjectively, so an objective method can be helpful. Ask your doctor what tests could be done to assess your current health condition. Do them before and after taking appropriate peptides
Why aren't there any similar peptide complexes from other companies?
First of all, the process of extracting peptides is patented. Secondly, Russian scientists started working on this class of medical substances 40 years ago at the request of the military, therefore they had access to all necessary funds. There were a 30-year study on rats, a study on apes and clinical trials. Nowadays just a few researches can be funded so well to be conducted on the same large scale.
Can Endoluten be consumed alongside any other supplements?
As they are each tailored to a specific gene, there is no problem with consuming multiple supplements at one time.
Can Endoluten be used to regulate sleep?
As it promotes melatonin secretion, Endoluten could be used to encourage a regular sleep pattern
Are there any known side effects for using this supplement?
Ventfort has been tested for many years on thousands of individuals, without reports of any serious side effects.
What combination of peptides should i take?
According to Prof. Vladimir Khavinson, the president of European Association of Gerontology and Geriatrics, the first class combination consists of Endoluten (Neuro-endocrine system), Vladonix (Immune system), Cerluten (Brain), Sigumir (Joints and Bones), Svetinorm (Liver) and Ventfort (Blood vessels) for one or two months twice a year. Endoluten and Vladonix are the two most important geroprotector that are able to extend life by 30-40%.
Here are some general recommendations:
Natural Peptides Combinations
Aging and protein synthesis
Aging is a major risk factor for disease and death but what is the cause of aging? Despite many theories it is still unknown. What we know is that as we age our body produces fewer proteins that have a large number of important functions in our body. For example:
Basically, our bodies make thousands of specific proteins that serve important roles in everyday functioning — in fact, the human body is about 45% protein on a dry matter basis.
As aging is associated with a decline in the synthesis of protein, it is logical to assume that if the synthesis is restored aging can be slowed down. As it turns out this assumption is correct. Scientists V. Khavinson and V. Morozov have found a way to repair protein production and have achieved incredible results. Using the following methods can increase lifespan by 20-40%
Triggering molecules
The information about different proteins is stored in the DNA. In order to launch protein synthesis a DNA fragment, a gene, has to be activated by triggering molecules, peptides. Peptides are relatively short chains of amino acids and they are an essential part of the cell self-regulating mechanism:
Cells constantly degrade aged proteins by breaking them down into amino acids and peptides. Some of these peptides match specific parts in the cell DNA following the lock-key principle. As a result, the peptide resumes the synthesis of the protein from which it was originally built. When the protein ages, it is fragmented into the same peptides once again. All of this forms a circular process that is vital to cell life.
However, due to extended exposure to environmental hazards and stress this cell self-regulating mechanism is compromised and we become peptide deficient. Peptide deficiency leads to cell malfunction and eventually to diseases and premature aging. Luckily, we can restore the peptide-protein cycle with peptide supplements.
History
The first peptide product was created for the military in the Russian Military Medical Academy 40 years ago in 1974 by V. Khavinson and V. Morozov since 1977 and it has been authorized for clinical use under the name Thymalin. It cointains thymus peptides, extracted from young calves, that restore the impaired immune system and minimize the risk of cancer by several times. Shortly, Epithalamin, a product formulated with the pineal gland peptides was developed. It prevents premature aging, improves the function of the endocrine, immune, cardiovascular and reproductive systems, lengthens telomeres, restores carbohydrate metabolism, and strengthens bones and joints. It was proven that if administrated together the pineal gland and the thymus peptides can prolong human life substantially. Their high efficiency has been shown in more than 50 experiments on animals and multiple clinical trials in the last 40 years.
Eventually, peptides have been extracted from almost every body system and demonstrated stunning tissue-specific properties, i.e., they have beneficial effects on the organs which they were extracted from.
In the last 40 years these medicines have been taken by more than 15 millions of people and no side effects have been found. The fact is that peptides are apparently evolutionary the oldest cell self-regulating mechanism and as their structure is quite simple they have not undergone any constructional changes over time. That means that peptides in animals and humans are identical. Besides it was also proven that peptide intake can only normalize the protein synthesis and cannot overstimulate it as a cell cannot take more peptides than it needs.
Peptide supplements
For many years the peptide preparations were available only as medicines, in the form of injections. However some years ago Prof. Khavinson and the St. Petersburg Institute of Bioregulation and Gerontology created dietary supplements that can also reduce peptide deficiency and restore peptide-protein cycle in cells. They can be divided into natural and synthesized peptides.
Natural peptides (Cytomaxes)
Natural peptides is a group of peptides of less than 50 amino acids and with a molecular mass of less than 5 kDa, free from foreign DNA or protein substance, extracted from organs and tissues of young calves by a patented method of thorough filtering. 5 kDa is very little. The molecular mass of DNA fragments and proteinaceous infectious particles, the prions, are several times bigger than that. Therefore these peptide supplements are extremely clean products. They do not have any immunogenic or mutagenic properties.
Inside the gastrointestinal tract the natural peptides break down into amino acids and di-, tri- and tetrapeptides that match the DNA in a complementary way and activate protein synthesis in the respective body system. Their performance is gentle and gradual. Their effect continues to grow even after finishing the supplementation course and lasts up to 4-6 months until the peptide-protein cycle is impaired again.
When and how to take peptides?
It is advised to start taking peptide supplements upon reaching 35 years of age as a preventive measure against premature aging. At this stage two to three 10-day courses of the basic products per year are sufficient to maintain the body's well-being. These basic products are Vladonix, Cerluten, Ventfort, Sigumir, Svetinorm and if a person works night shifts or often takes intercontinental flights, Endoluten. They regulate the function of the systems that age faster. If required, other peptides could be added as another ten-day course, based on individual needs.
Starting from 40-45 years, two courses a year become necessary, with 2 capsules daily for 30 days per course. The health in the decades to follow will majorly be influenced by the degree of recovery achieved during this period. It is crucial to start timely biannual intake of extensive anti-age courses that include Endoluten, Vladonix, Cerluten, Ventfort, Sigumir, Svetinorm, Chelohart and for men Libidon, Testoluten, for women Zhenoluten and Thyreogen. Additional products are chosen based on individual needs and predispositions. Generally, the older we get, the more organs that require additional support.
Starting from 50-55 years, it is generally recommended to increase the number of courses a year from two to three. If you need to take more than 5 peptide products it is usually advised to split the course in several months so that each month you take 5 products or fewer. Please note for better absorption peptides are taken 30 minutes before meals.
Conclusion
There is still no way to stop aging but thanks to the scientists' intensive work during the last 40 years, we finally have dietary supplements that substantially slow down aging by reducing peptide deficiency and restoring cell peptide-protein cycles in the body. There are 19 natural peptide products and 12 synthesized ones that cover almost every body system and organ. Thus, if you want to live longer being mentally and physically healthy you have now a real solution.
Suprefort is manufactured in the form of capsules, containing 10 mg of active peptides. Suprefort was administered per os 10-15 minutes before meal 1-2 capsules 2 times a day for 10-20 days depending on severity of the pathological process.
The clinical studies of Suprefort were carried out at the Medical Center of the Saint Petersburg Institute of Bioregulation and Gerontology in patients with Chronic pancreatitis in the state of remission and in patients with Diabetes mellitus II during the period from November 2005 till January 2006.
Deregulation of physiological functions and pathological changes in pancreas result in diseases with signs of nutrition and metabolism disorders. Consequences of progressive inflammatory process in pancreas are, as a rule, dystrophic processes accompanied with disorders of excretion of digestive pancreatic enzymes, characteristic for chronic pancreatitis. In the presence of disorders of insulin secretion, the patient has symptoms of ‘secondary’ diabetes mellitus.
Diabetes mellitus is one of most widespread endocrine diseases: about 1-2% of Earth’s population has it. Besides there are same amount of people with occult diabetes and genetically predisposed to this disease. The diabetes signs in any single case are integrated reaction to mutual action of multiple factors with various combinations (genetic predisposition, chemical and infectious agents of environment, autoimmune processes, nutrition, physical activity, psychological stresses etc.). Detection of new syndromes (diabetes, caused by formation of antibodies to insulin receptors; diabetes caused by genetic defects of insulin structure etc.) is a reason of constant necessity of addition of disease classification. Potential, latent and asymptomatic forms of the diseases without clinical symptoms require special attention concerning prognosis, prophylaxis and treatment (1, 3, 6, 7, 8). Treatment of chronic pancreatitis is based mainly on diet and enzyme preparations (pancreatin, pansinorm) etc. (5) Treatment of diabetes mellitus without clinical signs requires diet therapy and phytotherapy (2, 4).
Clinical characteristic of the patients
Distribution of the patients by diagnoses, sex and age is shown in the table 1. Treatment using Suprefort was carried out in 34 patients (18 male and 16 female) with diagnoses ‘Chronic pancreatitis, latent form’ (12 persons) and ‘Diabetes mellitus II type, latent form’ (22 persons). The patients with chronic pancreatitis were complaining of the loss of appetite, eructation, meteorism, borborygmus, stool disorders. Two groups of patients were formed using random sampling technique, in these groups the patients have similar sex, age and diagnosis: the basic group included 12 patients (8 men, 4 women), control group - 8 patients (4 men, 4 women).
Table 1
Distribution of the patients by diagnosis, sex and age
The patients of the control group have been taking general purpose medicines. The patients of the main group have been taking Suprefort in addition to the general purpose medicines - 1-2 capsules, 2 times a day before meal for 15 days.
Diabetes mellitus II in the patients was not accompanied by any clinical signs and was diagnosed on the basis of an increase in glucose level in peripheral blood in view of unbalanced diet.
Control group included 17 patients, who have been taking general purpose medicines. 22 patients of the main group have also been taking Suprefort in addition to the general purpose medicines - 1 capsule, 2 times a day before meal for 15 days.
Examination methods
The patient complaints were assessed and compared, general clinical studies of blood and urine were carried out together with blood biochemical test using ‘REFLOTRON’ device, (Boehringer Mannheim, Germany). Duodenal content was examined. Glucose tolerance test was carries out.
Examination results
It was established that administration of Suprefort in patients with chronic pancreatitis resulted in increase in appetite and decrease in the rate of dyspepsia.
Table 2
Suprefort influence of activity of digestive enzymes in patients with chronic pancreatitis
Laboratory assessment of duodenal content has shown initial decrease in activity of pancreatic enzymes (table 2). After Suprefort administration there is tendency toward increase in activity of pancreatic enzymes, which correlated with improved clinical symptoms.
Suprefort in patients with diabetes mellitus II was administered in parallel with glucose tolerance test. It was established that after glucose challenge the patients had characteristic glycemic curve. The patients of the main group have also been taking Suprefort in addition to the general purpose medicines - 1 capsule, 2 times a day before meal for 10 days. It was shown, that after Suprefort administration the test carried out in 2 hours after beginning of the study showed gradual decrease in the glucose level. In 5-10 days after beginning of the treatment course the patients had normal glucose levels. None of the patients had increased dosage of blood glucose lowering drugs, 12 patients (54,5%) were using decreased levels of general purpose medicines and in 7 patients (31,8%) the blood glucose level was below normal values without blood glucose lowering drugs. In 3 patients (13,6%) the parameters remained at the initial level. It is worth noting the stabilization of the blood glucose parameter in the patients of the main group within next 2-3 month after the end of treatment (table 3).
Table 3
Suprefort influence on blood glucose values after glucose loading in patients with diabetes mellitus II
In patients of the control group, who have been taking general purpose blood glucose lowering drugs, it was not possible to lower the dosage of the medicines, and in 9 patients (52,9%) the dosage of blood glucose lowering drugs was increased with a purpose of normalization of content of blood glucose.
Thus the results of the clinical study obtained confirm an efficiency of Suprefort and expediency of its use in complex treatment of the patients with chronic pancreatitis and diabetes mellitus II.
Suprefort does not result in side effects, complications and drug dependence. Suprefort is convenient for administration in hospital, out-patient conditions and at home. Suprefort can be used as medical and preventive mean in the form of biological active food additive and in the form of adjunct in combination with any means of symptomatic and pathogenetic therapy, used for treatment of patients with chronic pancreatitis and other diabetes mellitus II.
Conclusion
The dietary supplement Suprefort normalizes functional activity of pancreas cells.
Suprefort is well tolerated by patients at oral administration; it does not result in any side effects and can be widely used as a treatment and prophylactic biologically active food additive for complex treatment of pancreatic function disorders.
Recommended Suprefort dosage
In patients with chronic pancreatitis - per os 10-15 minutes before meal 1-2 capsules, 2 times a day for 15 days.
In patients with diabetes mellitus - per os 10-15 minutes before meal 1 capsule, 2 times a day for 15 days in parallel with blood glucose monitoring.
It is expedient to carry out another treatment course in 3-6 month if needed.
References
1.Balabolkin M.I. Diabetes mellitus / Endocrine disorders // Diagnostics and treatment of internal diseases: Manual for doctors. - Edited by F.I.Komarova. - M.: Medicine, 1991. - V. 2. - pages 465-492.
2. Belousov Y.B., Moiseev V.S., Lepakhin V.K. Clinical pharmacology and pharmacotherapy: Manual for doctors. - M.: Universum, 1993. - 398 pages
3. Internal diseases / Edited by A.S. Smetnev, V.G. Kukes. - M.: Medicine, 1982. - 496 pages
4. Yordanov D., Nikolov P., Boychinov Asp. Phytotherapy. - Sofia: Medicine and physical culture, 1972. - 346 pages
5. Mashkovsky M.D. Medicines: Pharmacotherapy for doctors, manual: 2 parts. - Vilnius: ZAO “Gamta”, 1993.
6. Geriatry manual / Edited by D.F. Chebotarev, N.B. Mankovsky. - M.: Medicine, 1982. - 544 pages
7. Teppermen G., Teppermen H. Physiology of metabolism and endocrine system: Translated from English. - M.: Mir, 1989. - 656 pages
8. Ugolev A.M., Radbil O.S. Digestive system hormones. - M.: Nauka, 1995. - 283 pagesDiabetes mellitusDiabetes mellitusDiabetes mellitusDiabetes mellitusDiabetes_mellitusDiabetes_mellitus
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